细胞穿膜肽作为皮肤渗透促进剂的研究进展

郭霞,曾珊珊,叶金翠*

中国药学杂志 ›› 2014, Vol. 49 ›› Issue (19) : 1677-1681.

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PDF(820 KB)
中国药学杂志 ›› 2014, Vol. 49 ›› Issue (19) : 1677-1681. DOI: 10.11669/cpj.2014.19.001
综 述

细胞穿膜肽作为皮肤渗透促进剂的研究进展

  • 郭霞,曾珊珊,叶金翠*
作者信息 +

Progress in Researches for Cell-Penetrating Peptides as Skin Penetration Enhancer

  • GUO Xia,ZENG Shan-shan,YE Jin-cui*
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文章历史 +

摘要

目的 综述细胞穿膜肽作为皮肤渗透促进剂的研究进展。方法 参考近年来国内外相关文献,对细胞穿膜肽的起源、分类以及在经皮给药系统中的应用等进行综述。结果 细胞穿膜肽是具有细胞膜穿透能力的小肽,能有效地促进核酸类、肽类、蛋白质类等生物大分子药物经皮吸收。结论 细胞穿膜肽作为一种新型的透皮给药渗透促进剂有巨大潜在的应用价值,但其促透机制需要更深入的研究。

Abstract

OBJECTIVE To review the progress in researches for cell-penetrating peptides as skin penetration enhancer. METHODS Based on the literatures in recent years published at home and abroad, the origin, classification and application of cell-penetrating peptides in the field of transdermal drug delivery system were introduced in the present paper. RESULTS Cell-penetrating peptides are small peptides that are able to transfer nucleic acids, peptides and proteins into skin effectively. CONCULSION As a novel skin penetration enhancer, the cell-penetrating peptides has enormous potential application value,but the mechanism of promoting penetration requires further study.

关键词

细胞穿膜肽 / 渗透促进剂 / 经皮给药系统 / 生物大分子药物

Key words

cell-penetrating peptide / penetration enhancer / transdermal drug delivery system / biological macromolecular drugs

引用本文

导出引用
郭霞,曾珊珊,叶金翠*. 细胞穿膜肽作为皮肤渗透促进剂的研究进展[J]. 中国药学杂志, 2014, 49(19): 1677-1681 https://doi.org/10.11669/cpj.2014.19.001
GUO Xia,ZENG Shan-shan,YE Jin-cui*. Progress in Researches for Cell-Penetrating Peptides as Skin Penetration Enhancer[J]. Chinese Pharmaceutical Journal, 2014, 49(19): 1677-1681 https://doi.org/10.11669/cpj.2014.19.001
中图分类号: R944   

参考文献

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基金

国家自然科学基金资助项目(30901871);卫生部科研基金(201231507);浙江省科技厅项目(2011C13003,2014F10034);浙江省卫生高层次创新人才培养工程项目;浙江省医学重点学科群建设(XKQ-010-001)
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